Abstract Background TetR-family transcriptional regulators (TFTRs) are DNA binding factors that regulate gene expression in bacteria.Well-studied TFTRs, such as AcrR, which regulates efflux pump expression, are usually encoded alongside target operons.Recently, it has emerged that there are many TFTRs which act as global multi-target regulators.Our
For many chronic fibrotic conditions, there is a need for local, sustained antifibrotic drug delivery.A recent trend in the pharmaceutical industry is the repurposing of approved drugs.This paper investigates drugs that are classically used for anthelmintic activity (pyrvinium pamoate (PYR)), inhibition of adrenal steroidgenesis (metyrapone (MTP)),
In terrestrial mammalian carnivore guilds, interspecific competitions (interferences and resource competitions) among sympatric species induce their ecological and behavioral patterns and population dynamics, thereby shaping community structures.Competitive species must partition their ecological niches for sympatry, while the extent of niche overl
Road deaths, injuries and property damage places a huge burden on the economy of most nations.Wyoming has one of the highest truck-related fatality rates among the states in the US.The high crash rates observed in the state is as a result of many factors mainly related to the challenging mountainous terrain in the state, which places extra burden o